Induction Theory of the final codes For Cancer
Given the unique role of proteins in cancer growth and metastasis of tumor protein inhibits production of medicines and treatments to stop or slow the holder or definitive treatment is effective tumor.
A brief mention of the role of proteins in tumors:
۱)Many tumors produce and secrete a polypeptide growth factors that stimulate the growth of the tumor.
۲) Many enzymes that play a role in metastasis and secreted by tumor cells and is involved in the breakdown of basement membrane proteins such as the plasmin.
۳) Many cancer genes activated by viruses, which encodes a protein that creates an autocrine sistem to grow and multiply.
For example, the virus HTLV 1 ATL retroviral disease that unlike other retrovirus env gene and a region between the fourth and 3- LTR is called tat, which encodes a protein that is at least 3 of them through work on 5- LTR enhances the transcription of HTLV1. It is more important to change the tat gene product activates genes, IL-2R and IL-2 in T cells infected with HTLV1 T cells produce cell growth factor T ((IL-2) ) and its receptor IL-2R is and Thus, an ironing system autocrine for growth to occur. This has led to the proliferation of polyclonal T cells, which is one of the initial events in leukemia.
۴) Several osteosarcoma cell lines, human C-sis Fibro sarcoma and transcribe humans glioma (glioma tumor of human) and the structure and immunological types of polypeptides that are similar to the PDGF release. Since the tumor cells with PDGF receptors are also activated PDGF-like mitogen always like that lead to the growth of tumor cells by autocrine fashion.
PDGF: Platelet-derived growth factor.
۵) Cytoplasmic protein tyrosine kinase activity, for example, cells that Rous sarcoma virus transformed by the protein kinase src produces and acts as a through route into inositol phospholipid transfer warning will stimulate mitosis.
۶) GTP binding proteins or protein Ras is the most common forms of cancer in humans oncogene change. Ras proteins located in the cell membrane with high affinity to bind GTP and GDP and GTP ase intrinsic activity continues to remain active Ras protein and the cell in such a way as if they were adenylate under the effect of continuous stimulation external alarm.
۷) C-Myc-related nuclear protein before Burkitt’s Limphoma Oncogeen C-Myc activation and production of a DNA binding protein that activates the alarm continuously sends DNA that can lead to deformation of the neoplasia.
۸) Activated by point mutations in 87% of breast cancers are caused by oncogene H-ras.
۹) The MLC leukemia hybrid C- abl-bcr gene is a chimeric protein that is tyrosine kinase activity.
۱)Inhibition of protein synthesis can be inhibited the cancer inhibitory proteins such as Rb protein growthy an inhibitory protein, so it should only drug on tumor cells become malignant inhibits protein synthesis.
۲)Inhibition of protein synthesis can be modified to remove parts of the DNA repair enzyme endonuclease and the DNA polymerase and Ligand Exonuclease and mutant DNA modification involved in the inhibition of cancer.
a) Induction UAG- UGA- UAA code to produce the final messenger RNA coding for the amino acid to induce the production of proteins in cancer cells.
b) One way to find tumor cells by tumor-specific markers of tumor markers in cancer cells, preferably on CD. For example: CD 15 in Hodgkin lymphoma. (Combination of amino acids induce the final code + CD monoclonal antibodies in cancer therapy with tumor specific markers unique to every person with cancer subtypes).
c) One method of drug delivery nanoparticles, method (polymerase d) If the codes are amplified by PCR and with the advent of recombinant DNA plasmid become and enter the tumor cells will lead to the production of tumor cells.
e) plasmid produced anywhere in Aug or methionine amino acid composition and immediately hit it suggests a code UAG- UGA- UAA. The monoclonal antibody against the cell nucleus or cytoplasm of cancer cells Aug code.
f) in all cells of the code may not be everyone Aug sample of cancer cells treated with unique performances.
Note: The code UGA can not induce mitochondrial in the final code. After UAG- UAA used.
Author and researcher: doctor Seyed Mohammad Reza Tabataba Naini
Translator and Press adviser : Behnam sedghi